Biochemistry
Syllabus for Spring 2003
Chemistry 471B
Biochemistry |
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Syllabus for Spring 2003 |
| Office:
Science 310 E-mail: DIimoto@Whittier.Edu Phone: x4421 |
Office Hours: Tuesday 10:00 - 11:30 AM Wednesday 2:00 - 3:00 PM Thursday 9:30 - 11:00 AM |
Text: Biochemistry by Christopher Mathews, K.E. Van Holde, and Kevin Ahern |
| We will cover chapters 9, 10, 12-16, 18, 20, and 23 this semester. There will be two exams and a final exam. Homework will be assigned as group work. In addition, there will be two papers and an oral presentation. The papers are an analysis of a journal article and will be 2-3 pages. The oral presentation will be based on the second paper. |
| Date | Topic | Chapter | Date | Topic | Chapter | |
| 2/7 - 2/19 | Membranes | 10 | 3/31-4/2 | Kreb's Cycle | 14 | |
| 2/19 - 2/26 | Signal Transduction | 23 | 4/4 -4/9 | Electron Transport Chain | 15 | |
| 3/3 | Discussion on Paper 1 | 4/11 | Exam II | 9, 12-15 | ||
| 2/28 - 3/7 | Antibodies | 7 | 4/14 - 4/16 | Pentose Phoshpate Pathway | 15 | |
| 3/10 | Exam I | 10, 23, and selected readings | 4/18 - 4/21 | Gluconeogenesis and Glycogen Metabolism |
16 | |
| 3/12 | Carbohydrates | 9 | 4/23 - 4/25 | Fatty Acid Metabolism | 18 | |
| 3/14 - 3/17 | Metabolism | 12 | 4/28 - 4/30 | Amino Acid Metabolism | 20 | |
| 3/14 | Paper 1 due | 5/2 | Selected Topic | |||
| 3/19-3/21 | Glycolysis | 13 | 5/5 - 5/9 | Oral Presentations | ||
| 5/12 | Review for Final Exam Paper 2 due |
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| 3/24 - 3//28 | Spring Break! | 5/16 (10:30 AM) | Final Exam | 15, 16, 18, 20, selected topic and oral presentations |
Grading |
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Aspartate Transcarbamoylase |
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| Exam I | 20% | Paper 1/Discussion | 10% | ||
| Exam II | 20% | Paper 2 | 9% | ||
| Final Exam | 25% | Oral Presentation | 6% | ||
| Homework | 8% | Seminar | 2% | ||
Paper 1
Download the following paper from the Journal of Biological Chemistry in the December 27th, 2002 issue. This journal is now on-line. Go to the electronic resources on the library webpage and click on on-line journals.
Tanowitz, Michael and von Zastrow, Mark. Ubiquitination-independent Trafficking of G Protein-coupled Receptors to Lysosomes. The Journal of Biological Chemistry. 277: 50219-50222 (2002).
Read the paper. Focus on the introduction and then the results and discussion. Then come back and read the materials and methods, if necessary, to help you understand anything that is unclear from the results and discussion. Consider the following questions to guide your reading.
1. What question(s) or hypothesis is(are) is being explored by the authors in this paper?
2. What background information is important in helping you understand the context for understanding the hypothesis being explored?
3. What overall conclusions do the authors draw from their experiments?
4. What is the purpose of each experiment conducted? Each key experiment can be identified by a figure or a graph.
5. What conclusions can be drawn from each experiment?
6. How do the conclusions of each experiment contribute to the overall conclusions of the authors?
Be prepared to discuss the paper in class on Monday, March 3.
Seminar
Friday, February 28 at 3:30 PM in Science 302.
Dr. Mark Warren
Xenoport Company
Inhibition of Bacterial Multi-Drug Efflux Pumps: Resistance is Futile
